Eine Überprüfung der Methadontabletten zur Schmerzbehandlung
Eine Überprüfung der Methadontabletten zur Schmerzbehandlung
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Methadone hydrochloride tablets can cause life-threatening heartbeat problems that can lead to death. Most heartbeat problems have happened rein people using large doses of methadone hydrochloride tablets for pain treatment.
The usual precautions appropriate to the use of parenteral opioids should Beryllium observed and the possibility of respiratory depression should always be kept rein mind.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death. Patients and caregivers should Beryllium instructed to keep methadone in a secure place out of the reach of children and to discard unused methadone hinein such a way that individuals other than the patient for whom it welches originally prescribed will not come hinein contact with the drug.
Methadone can be abused rein a manner similar to other opioid agonists, legal or illicit. This should Beryllium considered when prescribing or dispensing methadone hydrochloride tablets in situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.
Excretion – The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Published reports indicate that after multiple dose administration the terminal half-life (T1/2) welches highly parameter and ranged between 8 to 59 hours hinein different studies.
Dispose of any unused methadone hydrochloride tablets remaining from a prescription as soon as they are no longer needed. Unused Methadontabletten ohne Rezept online tablets should be flushed down the toilet.
The content rein this section is aimed at anyone involved in planning, implementing or making decisions about health and social responses.
These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration.
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not Beryllium able to clear this drug from your body well. This may increase the levels of methadone rein your body and cause more side effects. Your doctor should watch you closely if you take this drug.
Schulnote – Equianalgesic methadone dosing varies not only between patients, but also within the same patient, depending on baseline morphine (or other opioid) dose. Table 1 has been included hinein order to illustrate this concept and to provide a safe starting point for opioid conversion. Methadone dosing should not be based solely on these tables. Methadone conversion and dose titration methods should always be individualized to account for the patient's prior opioid exposure, general medical condition, concomitant medication, and anticipated breakthrough medication use.
This drug can make you very drowsy. You shouldn’t drive, use machinery, or do other activities that require alertness after you’ve taken this drug.
Physicians should individualize treatment rein every case (Tümpel DOSAGE AND ADMINISTRATION), taking into account the high degree of interpatient variability rein response to and metabolism of methadone.
Do not drink alcohol while using methadone hydrochloride tablets. It may increase the chance of having dangerous side effects.
Laboratory studies, both in vivo and in vitro, have demonstrated that methadone inhibits cardiac potassium channels and prolongs the QT interval. Cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have been observed during treatment with methadone. These cases appear to Beryllium more commonly associated with, but not limited to, higher dose treatment (> 200 Magnesium/day). Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction.